Pure Idiosyncraticness:
Examining DMT and the Affects on the Human Brain
By: Brittany Hall
The
air in the room gets sucked dry and all the colors become vibrant; as if they
were dancing strands of light. Half of your body feels like it has been stuck
with needles; while the other side is vibrating with excitement. A
humming sound fills your ears and gets louder and louder. Then you feel
yourself slip out of skin and you are thrown out into the universe. A door
unlike any door that you have ever seen appears to you and you fly through it
with a frightening speed. As you move further away from the door, you can feel
your humanity shedding off until the last layer drifts off into the continuum.
A giant kaleidoscope covers your eyes and all you can see is colors
interlocking and morphing together. The colors change into clouds and you don’t
know if you should be rejoicing with happiness or should be shivering with fear
and anticipation. Trying to grasp with this new reality of the environment that
has swollen you whole; you can’t come to a conclusion of this experience as
being your rebirth or your timely death. But time is enfolded here and merely
does not exist. The brilliant glow of a white light covers the plane and
grows brighter; as if the suns’ rays were embracing you with its fiery arms.
The white light becomes so intense, that you finally realize that the light is
coming within you. Then dimness softens the edges of
your vision and you fall on a feathery rupture right back into your body.
Doctors and researchers are
testing the potential of psilocybin and other hallucinogens.
Hallucinogens could possibly be used in the treatment of depression,
obsessive-compulsive disorder, post-traumatic stress disorder and alcoholism.
These drugs can also induce spiritual experiences. DMT is the only naturally
occurring psychedelic chemical in the human brain. This research paper will
explore the affects of DMT on the human mind naturally and induced; describing
what DMT is and digging up the history of the psychedelic chemical.
DMT
or also known as N, N-dimethyltryptamine; is found naturally in mammalian
brains, also found in many different species of plants and produced naturally
in the human brain. DMT is a root chemical that gives rise to many other
synthetic hallucinogenic tryptamines, including psilocin, psilocybin (“magic”
mushrooms) and 5-MeO-DMT ("DMT."). Dimethyltryptamine belongs in the
family of compounds called the hallucinogens or psychedelics; in which
includes: LSD (acid), psilocybin, and mescaline from the peyote cactus
("DMT, THE SPIRIT MOLECULE RESOURCES"). Structurally, DMT is
analogous to the neurotransmitter serotonin and also to the hormone melatonin;
in which these chemicals are produced in the pineal gland of the brain. The
pineal gland is located in the central part of our brains; in which produces
many important hormones. This pine cone shaped gland still remains a mystery
and it isn’t certain that it makes DMT but could be responsible in causing a
person to experience a psychedelic state.
Endogenous DMT is made within the body and was first discovered in rodents. Once scientists realized the structure of DMT, it was later discovered in humans. The synthesis of endogenous DMT begins with dietary tryptophan, going through many processes until it become tryptamine; then an enzyme will attach two methyl groups to a nitrogen atom on the tryptamine, resulting in "N, N-dimethyltryptamine" ("DMT, THE SPIRIT MOLECULE RESOURCES"). Below is a picture of N, N-dimethyltryptamine ("N, N-DIMETHYLTRYPTAMINE (DMT)."):
Endogenous DMT is made within the body and was first discovered in rodents. Once scientists realized the structure of DMT, it was later discovered in humans. The synthesis of endogenous DMT begins with dietary tryptophan, going through many processes until it become tryptamine; then an enzyme will attach two methyl groups to a nitrogen atom on the tryptamine, resulting in "N, N-dimethyltryptamine" ("DMT, THE SPIRIT MOLECULE RESOURCES"). Below is a picture of N, N-dimethyltryptamine ("N, N-DIMETHYLTRYPTAMINE (DMT)."):
DMT
is made in the lung and also in the red blood cells of the human body; yet it
is not known if the pineal gland actually produces DMT but the gland does
contain the necessary enzymes and building blocks for DMT synthesis.
The
first documented record of DMT in the history timeline was dated back in 1496
documented by Friar Ramon Pane. “Pane documented the use of psychoactive snuff
called cohoba/yopo among the Taino who inhabited the island of Hispaniola
Haiti/Dominican Republic ("Erowid DMT Vault : Timeline.")” The snuff
came from a plant called, Anadenanthera peregrine; in which is a plant known to
contain N, N- dimethyltryptamine. Snuff and potions of the South American
shamans and other indigenous people have used DMT for ritual practices and for
spiritual journeys for centuries. DMT was first synthesized in 1931, by a
British chemist named Richard Manske, whom named it "nigerine".
In 1956, the psychoactive effects of DMT was discovered by an Hungarian chemist
and psychiatrist Stephen Szára. Szára synthesized his own DMT in the hope that
he would find it to be ‘psychedelic. Szára thus became the first person to
recognize the psychedelic properties of DMT; in which he injected it into himself.
As the awareness and usage of
DMT started to spread in the psychopharmacology world and the underground
chemists; three writers: William S. Burroughs, Timothy Leary, and Ralph Metzner
explained the dangers of the drug; so in 1966 DMT was made illegal. Nick Sands
increased the popularity of DMT for users by discovering that it could be
smoked. Research on psychedelic drugs in the United States came to a halt in
the 1970’s due to the Scheduling Laws, which were passed by the Congress.
Almost twenty years later a psychiatrist named Rick Strassman’s received FDA
approved for his clinical trials on scientific investigation into the compound,
known as DMT (1990-1995). Dr. Strassman did a five year project; in which he administered
400 doses of DMT into 60 healthy patients at the University of New Mexico's
School of Medicine in Albuquerque. Strassman accompanied by others; supervised
these volunteers’ drug sessions to observe and collect biological and
psychological data. Many of the volunteers claimed that they dissolved into a
blissfulness of light and felt god-like; while some experienced the adverse
effects. Strassman describes the adverse effect by, which people will be
terrifying visions in which they see extraterrestrials. Due to the adverse
effects caused by the drug Strassman discontinued his work and published a book
in 2000 called, DMT: The Spirit Molecule.
DMT is commonly handled and stored as
a fumarate; in which is very hygroscopic and will not readily crystallize.
Another property of DMT fumarate is that its freebase form is not as stable but favored by
recreational users choosing to vaporize the chemical. Below is a picture of DMT
crystals ("Erowid DMT Vaults : Extraction : QT's DMT Extraction
Guide."):
DMT can be taken by many different methods; the less
effective way to take the drug is by oral consumption. Taking the drug orally
it is easily broken down in the stomach and the drug is inhibited; so therefore
the drug must be snorted, smoked or injected with. South American Indians side
stepped this issue by snuffing DMT and also by brewing ayahuasca (a concoction
of psychoactive infusions that is taken orally). Inhalation of 30 mg of DMT
would interrupt the threshold of activity and at administration of 50-70 mg; a
person is in a complete psychedelic experience. Within 5 minutes of administration
there is dilated pupils, rapid heartbeat, a measurable increase in blood
pressure, and related vegetative disturbances which usually persist throughout
the drug experience. In 10-15 minutes, the full intoxication is realized,
generally characterized by hallucinations with the eyes either open or closed,
and extensive movement within the visual field. There is difficulty in the
expression of one's thoughts, and in concentration on a given subject. There is
usually a mood change to the euphoric with unmotivated laughter,
but instances have been reported in which paranoid ideation has promoted
anxieties and feelings of foreboding into a state of panic. The subject is
largely symptom-free at 60 minutes, although some residual effects have been
seen in the second hour. With the inhalation route of administration the time
scale is contracted, with onset of effects noted in 10 seconds, a short period
of full intoxication at 2-3 minutes, and a complete freedom from any residual
effects within 10 minutes. An unusual feature of the induced intoxication is
the speed of onset and short duration; in which the drug was coined as the “the
businessman's trip"("DMT THE SPIRIT MOLECULE RESOURCES"). The
entire psychedelic trip can be over within 30 to 45 minutes, depending on how
it was introduced into the body.
However, DMT can be harmful to a person’s well being if
not taken properly. DMT introduced into a person’s systems does cause a rapid
increase in heart rate and blood pressure; very similar to the experience of
doing a short full out sprint. People with heart or blood vessel disease should
not try this drug due to the stress it will have on the cardiovascular system.
People with gastrointestinal problems should consider not ingesting ayahuasca;
in which induces vomiting and nausea for most people. People who are
psychological fragile should also avoid this drug because it could have a
profound effect on their well being. Nothing has been found on rather or not if
DMT causes and damage to the brain.
Since the 1970’s, DMT has belonged in the Schedule I of
the Controlled Substances Act; DMT is in
the same category of heroin, LSD, marijuana, mescaline, and psilocybin. “Schedule
I placement means that they are defined as 1) unsafe to use; 2) have no medical
use; 3) are highly abusabl ("DMT THE SPIRIT MOLECULE RESOURCES").”
DMT isn’t as popular as LSD or psilocybin; yet,
however ayahuasca is becoming more widely used today. The brewed drink is
becoming popular with Westerners traveling to South America who take it in
shamanic rituals, as well as shamans and ayahuasca-using churches making
inroads into the West. DMT was popularized in American by Terence McKenna, in
the early 1990’s. Terence Kemp McKenna was an American ethnobotanist,
philosopher, psychonaut, researcher, teacher, lecturer and writer on many
subjects; whom wanted to bring about a psychedelic revolutionary movement.
Mckenna describes his first experience with DMT:
"So
I did it and...there was a something, like a flower, like a chrysanthemum in
orange and yellow that was sort of spinning, spinning, and then it was like I
was pushed from behind and I fell through the chrysanthemum into another place
that didn't seem like a state of mind, it seemed like another place. And what
was going on in this place aside from the tastefully sufficed indirect
lighting, and the crawling geometric hallucinations along the domed walls, what
was happening was that there were a lot of beings in there, what I call
self-transforming machine elves. Sort of like jeweled basketballs all dribbling
their way toward me. And if they'd had faces they would have been grinning, but
they didn't have faces. And they assured me that they loved me and they told me
not to be amazed; not to give way to astonishment ("Descriptions of the
DMT Experience.").”
DMT
is a mysterious spirit molecule in which many different forms of life possesses
and
yet we don’t know why this is or why it is produced in our bodies. DMT can make you into a spiritual believer awestruck by the mysteries of nature and the human mind. Brain researchers may object to the suggestion that DMT affects the brain's ability to receive information rather than generate those perceptions themselves. They also may dismiss the proposal that DMT can allow our brains to perceive dark matter or parallel universes, realms of existence inhabited by conscious entities (Strassman). More research is needed to learn more about DTM and how it plays an important role in our bodies and conscious’s. Maybe one day we will be able to tap into this chemical and slip into a psychedelic state mind, without the ingestion of drugs. Being able to turn off and on our psychedelic world could allow us to evolve in more spiritually, religiously, creative beings with a whole new view of our reality.
yet we don’t know why this is or why it is produced in our bodies. DMT can make you into a spiritual believer awestruck by the mysteries of nature and the human mind. Brain researchers may object to the suggestion that DMT affects the brain's ability to receive information rather than generate those perceptions themselves. They also may dismiss the proposal that DMT can allow our brains to perceive dark matter or parallel universes, realms of existence inhabited by conscious entities (Strassman). More research is needed to learn more about DTM and how it plays an important role in our bodies and conscious’s. Maybe one day we will be able to tap into this chemical and slip into a psychedelic state mind, without the ingestion of drugs. Being able to turn off and on our psychedelic world could allow us to evolve in more spiritually, religiously, creative beings with a whole new view of our reality.